El efecto protector del ácido p-cumárico sobre la hepatotoxicidad, nefrotoxicidad y neurotoxicidad inducidas por tolueno en ratas

The protective effect of p-coumaric acid on toluene-induced hepatotoxicity, nephrotoxicity and neurotoxicity in rats

Contenido principal del artículo

Fatma Sahindokuyucu-Kocasarı
Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Burdur, Turkey
Selinay Basak Erdemli-Kose
Burdur Mehmet Akif Ersoy University, Faculty of Arts and Sciences, Department of Chemistry, Burdur, Turkey
Zeki Erol
Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Animal Experiments Production and Experimental Research Laboratory, Burdur, Turkey
Simge Garlı
Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Animal Experiments Production and Experimental Research Laboratory, Burdur, Turkey

Resumen

Objetivo. El objetivo de este estudio ha sido determinar el efecto protector del ácido p-cumárico (p-CA) contra la hepatotoxicidad, nefrotoxicidad y neurotoxicidad inducida por tolueno en ratas. Materiales y métodos. Se utilizaron un total de 32 ratas macho Sprague-Dawley, 8 en cada grupo. Se formaron 4 grupos: el de control, tolueno, p-CA y tolueno + p-CA. Los animales del grupo de control, el grupo de tolueno y el grupo de p-CA recibieron NaCl al 0.9%, 0.9 mg/kg de peso corporal de tolueno y 100 mg/kg de peso corporal de p-CA por vía oral durante 21 días, respectivamente. Resultados. En este estudio, se determinó que hubo aumentos significativos en las actividades de ALT y AST, y los niveles de creatinina en el grupo inducido por tolueno en comparación con el grupo de control. Además, hubo una disminución en las actividades de GSH-Px y los niveles de GSH, y un aumento en los niveles de MDA en comparación con el grupo de control. Sin embargo, en el grupo de tolueno + p-CA, se observaron disminuciones significativas en las actividades de las aminotransferasas, niveles de creatinina y MDA, y aumentos significativos en las actividades de GSH-Px y los niveles de GSH en comparación con el grupo de tolueno. Conclusiones. Se ha determinado que el p-CA tiene un efecto protector contra la hepatotoxicidad, nefrotoxicidad y neurotoxicidad inducidas por el tolueno.

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Biografía del autor/a (VER)

Fatma Sahindokuyucu-Kocasarı, Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Burdur, Turkey





Zeki Erol, Burdur Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Animal Experiments Production and Experimental Research Laboratory, Burdur, Turkey

 

 

 

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